2016–2021[]
In 2016, Onofre adopted a "cross" logo based on the "heart" logo of its then-parent company, CVS Health, which sold Onofre to RaiaDrogasil in 2019. Since then, Onofre stores were converted to RD's other brands, Droga Raia and Drogasil (the chain's flagship store, at Avenida Paulista, in São Paulo, was converted to the latter brand), and Onofre survived as an online-only brand until 2021, when Onofre's customer base was migrated to Droga Raia.