Fox 21 may refer to:
- Fox 21, a television production company owned by News Corporation from 2004 to 2014.
- Fox 21 Television Studios, a television production company formed by the merger of Fox 21 and Fox Television Studios in 2014; since rebranded as "Touchstone Television" in 2020.
- KQDS-TV in Duluth, Minnesota
- KXRM-TV in Colorado Springs, Colorado
- WFXR in Roanoke, Virginia (as "Fox 21/27")
- WHNS in Greenville, South Carolina
- WBOC-DT2 in Salisbury, Maryland
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