Originally signed on the air as KLEE-TV, a primary NBC affiliate on VHF channel 2, owned by hotelier W. Albert Lee.
Lee sold channel 2 to the Hobby family, owners of the Houston Post and Houston's oldest radio station, KPRC (950 AM) and KPRC-FM (99.7, now KODA at 99.1). The Hobbys took control of channel 2 on June 1, 1950, and changed the television station's callsign to the current KPRC-TV on July 3, 1950 to match its radio stations. The call letters stood for The Post Radio Company.
"Channel 2, let's all be there!" (1984–1985)
The "2" is also used by former sister station WESH in Orlando, also on channel 2.
The Hobbys decided to liquidate their company in 1992 after an attempt to sell its entire television station group to Young Broadcasting fell through, with KCCI and WESH being the first two sold to Pulitzer, Inc. for $165 million in 1993, and KPRC-TV and KSAT-TV to The Washington Post Company on April 22, 1994.