On October 9, 1986, KPTV became one of the original charter Fox affiliates (although still programmed as a de-facto independent station as the network would not start its full-time weekdays of programming until 1993).
In 1988, KPTV disaffiliated from Fox due to management concerns over the network's weak program offerings and their negative effects on its successful lineup, sending the affiliation to now sister station KPDX. It once again became independent after the switch and would not have the Fox affiliation until September 2, 2002.
KPTV once again became a Fox affiliate on September 2, 2002, as part of an affiliation swap between the two stations, following the UPN affiliation migrated to KPDX. It has since then branded itself as 'Fox 12 Oregon'.