Mizone was introduced on 27 September 2005.
The logo was slightly modified, mainly seen on the dot between the negative space that forms letter O was given a more 3D appearance. It initially appeared on Mizone Ur Flava Mangga Kweni bottles in March 2011, followed by the rest of flavors in late 2011.
In October 2016, Mizone received a new look based on its predecessors. The word "Isotonik" was also added below the logo.
On 11 March 2019, Mizone isotonic drinks were relaunched and reformulated as "White Isotonic", which actually based on its now-defunct "Fres'In" line. The entire new logo was added which for the first time from its early launch, didn't include the "letter O" negative space.