September 9, 2019–March 13, 2020
A series logo premiered on September 9, 2019. It was put on hiatus from March 16, 2020, to April 2020 due to the COVID–19 pandemic in the Philippines. It was preempted by 100 Days to Heaven as a result. However, due to the enhanced community quarantine in Luzon caused by the COVID-19 pandemic in the Philippines and the temporary closure of ABS-CBN due to the cease and desist order issued by the National Telecommunications Commission on account of its franchise expiration, the show was put on hiatus and was temporarily replaced by reruns of 100 Days to Heaven from March 16 until May 5, 2020.
On March 31, 2020, series lead Sylvia Sanchez and her husband, Art Atayde, tested positive for COVID-19.
On June 13, 2020, RGE Drama Unit confirmed the cancellation of Pamilya Ko through its official Instagram account. No reason was given. The announcement came a week after the cancellation of Make It with You due to the health concerns of its lead actress Liza Soberano, as well as the enhanced community quarantine in Luzon and the ABS-CBN franchise renewal controversy.