Channel 22 was launched on June 7, 1953, as WGBI-TV. It was owned by the Megargee family and its company, Scranton Broadcasters, along with WGBI radio (910 AM, now WAAF; and 101.3 FM, now WGGY).
WGBI went into a limited partnership with the now-defunct Philadelphia Bulletin in 1958 and was renamed WDAU-TV after WCAU-TV in Philadelphia, which was also owned by the newspaper. The FCC ruled that there was so much signal overlap between the two stations that they were effectively a duopoly. Its Grade B signal reaches the Lehigh Valley, which is part of the Philadelphia market. The Bulletin opted to retain WDAU-TV, and sold WCAU-TV to CBS. The Bulletin sold back WDAU to the Megargees a year later.
Scranton Broadcasters then sold the station to Keystone Broadcasters in 1984.
Keystone in turn, sold the station to Diversified Communications of Portland, Maine in 1986, with the call letters changed to the current WYOU on October 9. It kept its stylized 22, but now italicized.
Channel 22 was purchased by Nexstar Broadcasting as its first station property in 1996. In 1998, Nexstar bought rival WBRE-TV and "sold" WYOU to Mission Broadcasting, but kept control of WYOU's operations under a joint sales agreement with WBRE as the senior partner.
1Nexstar operates these stations owned by Mission Broadcasting. 2Nexstar operates this station owned by Cunningham Broadcasting. 3Nexstar operates this station owned by White Knight Broadcasting through an SSA. 4Nexstar operates this station owned by Vaughan Media. 5Predecessor company of LIN Media. 6Currently a repeater for WWLP. 7Joint venture with Warner Bros. Discovery in which Nexstar owns 31% while Warner Bros. Discovery owns the remaining 69%.